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Contraindicated (one)pentobarbital will lessen the extent or outcome of lumacaftor/ivacaftor by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the level or impact of brexpiprazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Double brexpiprazole dose about 1-2 months if